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Now long term survival is possible in some stage IV solid cancers with the use of targeted, hormonal, chemotherapy drugs. The list includes: 1) Stage IV hormone receptor positive metastatic breast cancer. 2) Stage IV her2 nu positive metastatic breast cancer. 3) Metastatic prostate cancer. 4) Left sided k-ras wild type colon cancer. 5) Metastatic gastrointestinal stromal tumors. 6) EGFR mutation positive metastatic lung cancer. 7) ALK positive metastatic lung cancer. 8) Metastatic malignant melanoma. 9) Metastatic Low grade Neuroendocrine tumors. 10) Some metastatic salivary gland tumors. 11) Platinum sensitive relapse epithelial ovarian cancer. 12) Germ cell tumors. 13) Metastatic Renal cell carcinoma. Long term survival is also possible in certain incurable haematological malignancy. These include: 1) Chronic leukemia- CLL. 2) Chronic Myeloproliferative disease- Polycythemia vera, essential Thrombocythemia, CML. 3) Multiple myeloma.