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Few important clinical pearls in Stage III NSCLC! Stage III NSCLC is a heterogeneous disease and carefully selected patients have better survival when surgery is integrated as a part of multimodality treatment approach. MRI brain with contrast should be an integral part of work up in stage III NSCLC lung cancer. PET-CT is important for mediastinal nodal staging but histopathological proof is required for confirmation. EBUS-TBNA is usually the first step to confirm mediastinal lymph node involvement . No role of routine adjuvant concurrent Chemo radiotherapy after surgery. But if adjuvant radiotherapy is given then it should be given after completion of chemotherapy. No role of routine consolidation chemotherapy after radical CT-RT in stage III NSCLC.