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-CNS relapse is a rare but fatal event in NHL patients. - It seems to be rarer and later in rituximab era. -CNS prophylaxis is associated with sever neurotoxicity. -Risk scores to predict CNS relapse display low sensitivity. -Prophylaxis is recommended in some extranodal and high IPI patients. -Adequate prophylaxis with high dose MTX +/-HD-araC. -Controversial role for intrathecal chemo and rituximab. *source- summary slide Dr ANDREAS FERRERI- at best of ICML 2017 , MUMBAI